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Advanced Instructor 111 Price Hall (0331) Phone: (540) 231-6155
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Education | Research Interests | Teaching | Grants | Experience | Recognition and Awards | Poster Presentations | Selected Publications
- Ph.D., Dept. of Plant Pathology, Physiology, and Weed Science, Virginia Tech, 1997
- M.S., Dept. of Poultry Science, North Carolina State University, Raleigh, 1980
- B.S., Dept. of Biology and Poultry Science, North Carolina State University, Raleigh, 1977
My research in collaboration with faculty in the Dept. of Animal and Poultry Science and Israel, is focused on the role of histones and DNA methylation modifications at critical control sites in the brains of chickens upon exposure to early thermal and nutritional stress. Findings from this research will show the potential role of histone 3 methylation status in early thermal and feed stress responses in chicks and may be indicative of an epigenetic mechanism for later adaptation to these stresses. Information learned from this research may lead to improvements of stress resistance in high yield poultry breeds using epigenetic adaptation approaches in order to improve animal welfare even under suboptimum environmental conditions.
Another focus of my research involves studying the feasibility of using medicinal plants as alternative sources of antibiotics in poultry feed for growth promotion and disease prevention. There has long been an interest in screening plants and their derived natural products for biological activity, often with the aim of producing new drugs. A growing body of evidence suggests that medicinal plants are good candidates for developing new agents for the treatment and prevention of bacterial infections. Widespread use of antimicrobials in humans and animals such as poultry has been paralleled by an increase in resistance in those bacteria such as Salmonella and Campylobacter that can spread from animals, often through food, to cause infections in humans. The indiscriminate use of antibiotics could ultimately compromise the treatment of bacterial infections in humans as many of these drugs are identical to or closely resemble drugs used in human medicine. My research may provide potential new sources of plant-derived antibiotics thus decreasing reliance on standard antibiotics and risking increases in bacterial resistance spreading from animals to the environment and more importantly into the food production chain.
- PPWS 3505 - Plant Physiology and the Environment
- PPWS 3506 - Plant Physiology and the Environment
- PPWS 3514 - Plant Physiology Laboratory
- ENT/PPWS 5624 - Animal and Plant Biosafety and Biosecurity
- Meiri, N., Denbow, D.M., Denbow, C.J. Nov. 1, 2009-Oct. 31, 2012. Epigenetic Adaptation: The Regulatory Mechanisms of Hypothalamic Plasticity That Determine the Stress-Response Set Point. BARD. Amount: $300,000. 25% participation.
- Advanced Instructor, Dept. of Plant Pathology, Physiology, and Weed Science, Virginia Tech, 2010-present
- Instructor, Dept. of Plant Pathology, Physiology, and Weed Science, Virginia Tech, 2008-2010
- Research Scientist (hard-funded research faculty), Dept. of Plant Pathology, Physiology, and Weed Science, Virginia Tech, 1997-2008
- Ph.D graduate student (part-time, while working full-time), Dept. of Plant Pathology, Physiology, and Weed Science, Virginia Tech, 1988-1997
- Laboratory Specialist Senior, Dept. of Plant Pathology, Physiology, and Weed Science, Virginia Tech, 1986-1997
- Laboratory Specialist A, Dept. of Dairy Science, Virginia Tech, 1984-1986
- Laboratory Specialist A, Dept. of Biology, Virginia Tech, 1981-1984
- Laboratory Technician A, Dept. of Agronomy, Virginia Tech, 1980-1981
- 2010 - Promotion to Advanced Instructor
- 2009 - CALS Certificate of Teaching Excellence Award
- 2009 - Master Online Instructor Certificate, Institute for Distance and Distributed Learning
- Bova, Jake, Nancy Troyano, Eric Sheppard, Cynthia Denbow, Carlyle Brewster, and Sally Paulson. 2011. Emergence of Lyme Disease Activity in Southwest Virginia. ESA Annual Meeting. November 13-16.
- Huff, Karleigh, Renee Boyer, Sean O'Keefe, Cynthia Denbow, and Robert Williams. 2011. The isolation of bacterial growth suppressing and growth promoting compounds from jalapeno pepper extract using liquid chromatography. International Association for Food Protection Annual Meeting, Milwaukee, WI. July 31-Aug. 3.
- Huff, Karleigh, Renee Boyer, Cynthia Denbow, Sean O'Keefe, and Robert Williams. Survival of Salmonella enterica on the surface and internal components of jalapenos. Journal of Food Protection. In Press.
- Xu, Pingwen, Cynthia J. Denbow, Noam Meiri, and D. Michael Denbow. 2011. Fasting of 3-day-old chicks leads to changes in histone H3 methylation status. Physiology and Behavior. 105:276-282.
- Denbow, C.J., S. Lang, and C.L. Cramer, 1996. The N-terminal domain of tomato 3-hydroxy-3-methylglutaryl-CoA reductases: sequence, microsomal targeting, and glycosylation. J. Biol. Chem. 271:9710-9715
- Weissenborn, D.L., C.J. Denbow, M. Laine, S.S. Lang, Z. Yang, X. Yu, and C.L. Cramer, 1995. HMG-Co A reductase and terpenoid phytoalexins: molecular specialization within a complex pathway. Physiol. Plant. 93:393-400
- Cramer, C.L., D. Weissenborn, C.K. Cottingham, C.J. Denbow, J.D. Eisenback, D.N. Radin, and X. Yu, 1993. Regulation of defense-related gene expression during plant-pathogen interaction. J. Nematology 25:507-518
- Park, H., C.J. Denbow, and C.L. Cramer, 1992. Structure and nucleotide sequence of tomato HMG2 encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase. Plant Mol. Bio. 20:327-331
- Denbow, C.J., K.S. Perera, F.C. Gwazdauskas, R.M. Akers, R.E. Pearson, and M.L. McGilliard, 1986. Effect of season and stage of lactation on plasma glucose and insulin following glucose injection in Holstein cattle. J. Dairy Sci. 69:211-216
- Denbow, C.J., J.M. Conroy, and K.D. Elgert, 1984. Macrophage-derived prostaglandin E2 modulation of the mixed lymphocyte reaction: an anomaly of increased production and decreased T cell susceptibility during tumor growth. Cellular Immunol. 84:1-13
- Jones, C.A., F.W. Edens, and D.M. Denbow, 1981. Rectal temperature and blood chemical responses of young chickens given E. coli endotoxin. Poultry Sci. 60:2189-2194
- Jones, C.A., F.W. Edens, and D.M. Denbow, 1982. Peripherally administered cations do not modify febrile responses induced in chickens by Escherichia coli. Poultry Sci. 61:1322-1328
- Jones, C.A., F.W. Edens, and D.M. Denbow, 1983. Influence of age on the temperature response of chickens to E. coli and S. typhimurium endotoxins. Poultry Sci. 62:1553-1558